genetics Gene Mutation May Prevent Alzheimer's Recent research has shown the possibility of a genetic mutation that could prevent people from developing Alzheimer's disease. July 02, 2015 Written By: Dementia.org Published On July 02, 2015 Scientists have long been frustrated with a lack of viable discoveries to prevent or thoroughly treat Alzheimer's disease. But a new genetic mutation may hold the key to preventing the development of Alzheimer's in the general population. Please Read This: Potential Advance In Reversing Effects Of Alzheimer's The Gene Mutation Scientists have recently discovered a rare mutation in human DNA which may contribute to the prevention of Alzheimer's development. The mutation is found in a gene known as APP, and affects a part of genetic code with a single differentiation in one of its bases. Ordinarily, the gene contains the genetic information that forces proteins in the body to break down into smaller components. One of these components is known as beta amyloid, a compound suspected of initiating early onset of Alzheimer's disease by building up in massive quantities in the brain. Other mutations of the APP gene have been discovered in the past, but most of them actually increase the quantities of beta amyloid,contributing to faster amyloid plaque buildup in the brain. The most recently discovered mutation affects the gene by reversing this tendency. It is thought that this strain actually disrupts one of the enzymes responsible for breaking down protein, reducing the beta amyloid formation in the body by up to 40 percent. This hypothesis is further substantiated by research showing carriers of this mutation over the age of 85 are seven and a half times less likely to develop Alzheimer's disease, than their ordinary-gene carrying counterparts. You Might Like This: Colombian Family Plagued With Early-Onset Alzheimer's The Importance Of The Study Other mutations have been found to protect against the development of Alzheimer's disease, such as the previously studied APOE2 allele, which breaks down beta amyloids within and between cells. But the new APP mutation is thought to have more significant effects, reducing the aggregation of beta amyloids to a much greater degree. The study also lends more evidence to the science of beta amyloids as the biggest indicator or cause of Alzheimer's disease. Possibilities For Future Drug Development Previous tests of experimental drugs have targeted the elimination of the buildup of beta amyloids in the brain, but the failure of these drugs has led to questioning as to whether targeting beta amyloids effectively prevents Alzheimer's. New theories suggest that these types of drugs will always be ineffective, because they take action only after the damage has been done. A successfully developed treatment eliminating beta amyloid buildup before it occurs may effectively prevent Alzheimer's disease from ever occurring. However, such a drug would be years away, and require further research and biological development, but the notion is promising in a field with few viable hopes for preventative treatment in decades. The mutation of APP may be years away from leading to a useful pharmaceutical development, but with a 750% drop in Alzheimer's development among the population with the gene mutation, the potential future for the treatment is enormous.0636 Recommended Articles medication Crenezumab: Can It Postpone Alzheimer's? alzheimers disease Colombian Family Plagued With Early-Onset Alzheimer's caregiver More Men As Caregivers For Female Dementia Patients alzheimers disease Potential Advance In Reversing Effects Of Alzheimer's alzheimers disease Detect Alzheimer's Risk 25 Years In Advance Most Searched Types Alzheimer's Huntington's Disease Parkinson's Disease Creutzfeldt-Jakob Disease Early-Onset Dementia Tags: genetics prevention alzheimers disease medication treatment research Learn More: End Stage Of Dementia The Montreal Cognitive Assessment (MoCA) The Mini Mental Status Exam (MMSE) Should I See A Psychiatrist, Or A Neurologist? Early-Onset Dementia Dementia Grief – What Makes It Unique?